Carcass Compound Materials Base on Fluoropolymer for Tissue Engineering in Orthopedics

Abstract

In this work new type of composite materials for application as coatings for intramedullary implants in the field of orthopaedics and traumatology is offered. Method is based on ability of fluoropolymers to act as biologically inert binding agent and ability of fine-dyspersated hydroxyapatite powders to act as biologically active filling agent providing osteoinduction and osteoconduction processes. Results of investigations of adhesion, elastic and morphometric characteristics of offered composite were presented; chemical composition was determined. Estimation of toxicological properties, locally irritant action and hemolytic activity of offered composites was done according to GOST R ISO 10993. In vivo tests were carried out; it was shown that offered composites didn’t cause any negative tissue reactions and stimulated osteogenesis processes in ectopic bone formation test. Key words: Carcass Compound Materials; fluoropolymers; orthopaedic